Rajkumar Thangarajan, M.D., D.M., Ph.D.
Cancer Institute (WIA)
Department of Molecular Oncology
Adyar
Chennai - 600 036
Tamil Nadu
E-mail: drtrajkumar@gmail.com, cancer_institute_wia@vsnl.com
Phone: +91-44-2350131; 2350241
Fax: +91-44-4912085
URL: http://www.cancerinstitutewia.org/staff.htm
Area of Specialization:
Medical Oncology
Research Summary:
Cell cycle regulatory molecules in cervical cancer
BCL-2 and p53 expression in cervical cancers
Study of type 1 tyrosine kinase growth factor receptors and their growth factors in breast and cervical cancers has been completed. The receptors studied include EGFR, c-erbB2 and the growth factors include Amphiregulin, Cripto, and Heregulin
PCR based detection of Minimal residual disease in Acute lymphoblastic leukemias
Publications:
1.
Rajkumar, T. , Sabitha, K., Vijayalakshmi, N., Shirley, S., Bose, M. V., Gopal, G. and Selvaluxmy, G. Identification and validation of genes involved in cervical tumourigenesis. BMC Cancer. 2011. 11, 80. [PubMed]
2.
Rajkumar T. Personalized medicine: FAQs. Indian Journal of Medical and Paediatric Oncology. 2010. 31, 72-74. [PubMed]
3.
Rajkumar, T. , Vijayalakshmi, N., Gopal, G., Sabitha, K., Shirley, S., Raja, U. M. and Ramakrishnan, S. A. Identification and validation of genes involved in gastric tumorigenesis. Cancer Cell International. 2010. 10, 45. [PubMed]
4.
Rajkumar, T. , Vijayalakshmi, N., Sabitha, K., Shirley, S., Selvaluxmy, G., Bose, M. V. and Nambaru, L. A 7 gene expression score predicts for radiation response in cancer cervix. BMC Cancer. 2009. 9, 365. [PubMed]
5.
Sudhakar, N., Nancy, N. K., Rajalekshmy, K. R. and Rajkumar, T. Diversity of T-cell receptor gene rearrangements in South Indian patients with common acute lymphoblastic leukemia. Iranian Journal of Immunology : IJI. 2009. 6, 141-146. [PubMed]
6.
Soumittra, N., Meenakumari, B., Parija, T., Sridevi, V., Nancy, K. N., Swaminathan, R., Rajalekshmy, K. R., Majhi, U. and Rajkumar, T. Molecular genetics analysis of hereditary breast and ovarian cancer patients in India. Hereditary Cancer in Clinical Practice. 2009. 7, 13. [PubMed]
7.
Nambaru, L., Meenakumari, B., Swaminathan, R. and Rajkumar, T. Prognostic significance of HPV physical status and integration sites in cervical cancer. Asian Pacific Journal of Cancer Prevention : APJCP. 2009. 10, 355-360. [PubMed]
8.
Murhekar, K. M., Anuratha, J. N., Majhi, U. and Rajkumar, T. Expression of human chorionic gonadotropin beta in gastric carcinoma: A retrospective immunohistochemical study. Indian Journal of Medical and Paediatric Oncology. 2009. 30, 99-102. [PubMed]
9.
Samson, M., Rama, R., Swaminathan, R., Sridevi, V., Nancy, K. N. and Rajkumar, T. CYP17 (T34C), CYP19 (Trp39Arg), and FGFR2 (C906T) polymorphisms and the risk of breast cancer in south Indian women. Asian Pacific Journal of Cancer Prevention : APJCP. 2009. 10, 111-114. [PubMed]
10.
Suneetha, K. J., Nancy, K. N., Rajalekshmy, K. R., Sagar, T. G. and Rajkumar, T. Role of GSTM1 (Present/Null) and GSTP1 (Ile105Val) polymorphisms in susceptibility to acute lymphoblastic leukemia among the South Indian population. Asian Pacific Journal of Cancer Prevention : APJCP. 2008. 9, 733-736. [PubMed]
11.
Sasikala, P. S., Nirmala, K., Sundersingh, S., Mahji, U. and Rajkumar, T. Frequency and distribution of Epstein-Barr virus infection and its association with P53 expression in a series of primary nodal non-Hodgkin lymphoma patients from South India. International Journal of Laboratory Hematology. 2010. 32, 56-64. [PubMed]
12.
Rajkumar, T. and Yamuna, M. Multiple pathways are involved in drug resistance to doxorubicin in an osteosarcoma cell line. Anti-cancer Drugs. 2008. 19, 257-265. [PubMed]
13.
Sudhakar, N., Nirmala, K., Rajalekshmy, K. R. and Rajkumar, T. Does TAL-1 deletion contribute to the high incidence of T-cell acute lymphoblastic leukemia in South Indian patients? Asian Pacific Journal of Cancer Prevention : APJCP. 2008. 9, 127-130. [PubMed]
14.
Vijayalakshmi, N., Selvaluxmi, G., Majhi, U. and Rajkumar, T. Alterations found in pl6/Rb/cyclin D1 pathway in the dysplastic and malignant cervical epithelium. Oncology Research. 2007. 16, 527-533. [PubMed]
15.
Murhekar, K., Majhi, U., Sridevi, V. and Rajkumar, T. Does "ichthyosis uteri" have malignant potential? A case report of squamous cell carcinoma of endometrium associated with extensive ichthyosis uteri. Diagnostic Pathology. 2008. 3, 4. [PubMed]
16.
Rajkumar, T. , Samson, M., Rama, R., Sridevi, V., Mahji, U., Swaminathan, R. and Nancy, N. K. TGFbeta1 (Leu10Pro), p53 (Arg72Pro) can predict for increased risk for breast cancer in south Indian women and TGFbeta1 Pro (Leu10Pro) allele predicts response to neo-adjuvant chemo-radiotherapy. Breast Cancer Research and Treatment. 2008. 112, 81-87. [PubMed]
17.
Samson, M., Swaminathan, R., Rama, R., Sridevi, V., Nancy, K. N. and Rajkumar, T. Role of GSTM1 (Null/Present), GSTP1 (Ile105Val) and P53 (Arg72Pro) genetic polymorphisms and the risk of breast cancer: a case control study from South India. Asian Pacific Journal of Cancer Prevention : APJCP. 2007. 8, 253-257. [PubMed]
18.
Sudhakar, N., Nancy, N. K., Rajalekshmy, K. R., Ramanan, G. and Rajkumar, T. T-cell receptor gamma and delta gene rearrangements and junctional region characteristics in south Indian patients with T-cell acute lymphoblastic leukemia. American Journal of Hematology. 2007. 82, 215-221. [PubMed]
19.
Parija, T., Shirley, S., Uma, S., Rajalekshmy, K. R., Ayyappan, S. and Rajkumar, T. Type 1 (11;22)(q24:q12) translocation is common in Ewing's sarcoma/peripheral neuroectodermal tumour in south Indian patients. Journal of Biosciences. 2005. 30, 371-376. [PubMed]
20.
Rajkumar, T. , Soumittra, N., Vidubala, E., Sridevi, V., Mahajan, V., Ramanan, S. and Vijaya, S. Organization and running of the first comprehensive hereditary cancer clinic in India. Hereditary Cancer in Clinical Practice. 2005. 3, 165-170. [PubMed]
21.
Rajkumar, T., Soumittra, N., Pandey, D., Nancy, K. N., Mahajan, V. and Majhi, U. Mutation analysis of hMSH2 and hMLH1 in colorectal cancer patients in India. Genetic Testing. 2004. 8, 157-162. [PubMed]
22.
Raj, E. H., Skinner, A., Mahji, U., Nirmala, K. N., Ravichandran, K., Shanta, V., Hurst, H. C., Gullick, W. J. and Rajkumar, T. Neuregulin 1-alpha expression in locally advanced breast cancer. Breast. 2001. 10, 41-45. [PubMed]
23.
Rajkumar, T. , Soumittra, N., Nancy, N. K., Swaminathan, R., Sridevi, V. and Shanta, V. BRCA1, BRCA2 and CHEK2 (1100 del C) germline mutations in hereditary breast and ovarian cancer families in South India. Asian Pacific Journal of Cancer Prevention : APJCP. 2003. 4, 203-208. [PubMed]
24.
Franceschi, S., Rajkumar, T. , Vaccarella, S., Gajalakshmi, V., Sharmila, A., Snijders, P. J., Munoz, N., Meijer, C. J. and Herrero, R. Human papillomavirus and risk factors for cervical cancer in Chennai, India: a case-control study. International Journal of Cancer. Journal International Du Cancer. 2003. 107, 127-133. [PubMed]
25.
Rajkumar, T. , Franceschi, S., Vaccarella, S., Gajalakshmi, V., Sharmila, A., Snijders, P. J., Munoz, N., Meijer, C. J. and Herrero, R. Role of paan chewing and dietary habits in cervical carcinoma in Chennai, India. British Journal of Cancer. 2003. 88, 1388-1393. [PubMed]
26.
Rajkumar, T. , Sridhar, H., Balaram, P., Vaccarella, S., Gajalakshmi, V., Nandakumar, A., Ramdas, K., Jayshree, R., Munoz, N., Herrero, R., Franceschi, S. and Weiderpass, E. Oral cancer in Southern India: the influence of body size, diet, infections and sexual practices. European Journal of Cancer Prevention . 2003. 12, 135-143. [PubMed]
27.
Vijayalakshmi, N., Selvaluxmi, G., Mahji, U. and Rajkumar, T. C-myc oncoprotein expression and prognosis in patients with carcinoma of the cervix: an immunohistochemical study. European Journal of Gynaecological Oncology. 2002. 23, 135-138. [PubMed]
28.
Nirmala, K., Rajalekshmy, K. R., Raman, S. G., Shanta, V. and Rajkumar, T. PCR-heteroduplex analysis of TCR gamma, delta and TAL-1 deletions in T-acute lymphoblastic leukemias: implications in the detection of minimal residual disease. Leukemia Research. 2002. 26, 335-343. [PubMed]
29.
Rajkumar, T. , Rajan, S., Baruah, R. K., Majhi, U., Selvaluxmi, G. and Vasanthan, A. Prognostic significance of Bcl-2 and p53 protein expression in stage IIB and IIIB squamous cell carcinoma of the cervix. European Journal of Gynaecological Oncology. 1998. 19, 556-560. [PubMed]
30.
Jayashree, B., Visalakshi, V., Rajalakshmi, K. R., Sukumaran, M. S., Moni, M. S., Rajkumar, T. and Deshmukh, S. Characterization of mouse fibroblast (NIH3T3) and fibrosarcoma cell lines (WEHI-164 and MFS 8) using PMRS. Indian Journal of Biochemistry & Biophysics. 1998. 35, 108-114. [PubMed]
31.
Shiekh, A. A., Sagar, T. C., Maitreyan, V., Rajkumar, T. , Majhi, U. and Shanta, V. Secretory immunoblastic lymphoma. The Journal of the Association of Physicians of India. 1994. 42, 155-156. [PubMed]
32.
Rajkumar, K., Rajkumar, T. , Sagar, T. G., Maitreyan, V. and Shanta, V. Cryptococcal meningitis in a patient with Hodgkin's lymphoma. The Journal of the Association of Physicians of India. 1992. 40, 707-708. [PubMed]
33.
Rajkumar, T. , Maitreyan, V., Sagar, T. G., Raj, E., Chandrasekhar, A., Mayilvahanan, N., Vasanthan, A., Sukumaran, M. S. and Shanta, V. Induction chemotherapy in non-metastatic high grade osteo sarcomas--results of pilot study at Cancer Institute (WIA), Madras. Indian Journal of Cancer. 1992. 29, 139-142. [PubMed]
34.
Rajkumar, T. , Sagar, T. G., Maitreyan, V., Vasanthan, A., Devika, A., Sastry, D. V. and Shanta, V. Germ-cell tumours of the ovary--treatment and results at Cancer Institute, Madras. Indian Journal of Cancer. 1992. 29, 18-23. [PubMed]
35.
Rajkumar, K., Rajkumar, T. , Sagar, T. G., Maitreyan, V. and Shanta, V. Cryptococcal meningitis in a patient with Hodgkin's lymphoma. The Journal of the Association of Physicians of India. 1991. 39, 785. [PubMed]
36.
Kumar, L., Rajkumar, T. , Raghunath, R. a. o., Usha, D., Sagar, T. G. and Shanta, V. Intrathecal methotrexate toxicity. The Journal of the Association of Physicians of India. 1989. 37, 351. [PubMed]
Education
::
M.B.B.S. in General Medicine,
Madras Medical College, University of Madras, India, 1975-1982
::
M.D. in General Medicine,
Madras Medical College, University of Madras, India, 1982-1985
::
D.M.
Madras Medical College, University of Madras, India, 1986-1988
::
Ph.D. in Medical Oncology
, 1991-1994
Honors and Awards
::
Visiting Professor, Dept. of Clinical Oncology, RPMS and Hammersmith Hospital, London, UK
::
Commonwealth Scholarship for 1991, tenable at Royal Postgraduate Medical School, Hammersmith Hospital, London, for Cancer Research
::
Inventor's Award from Imperial Cancer Research Fund, UK
::
2008, Shri Ramniklal J Kinarivala Cancer Research Award
::
Dr. Edmund Leorde Chalke Prize - Best Post-graduate in Medicine
Member
::
Fellow of the National Academy of Medical Sciences, India
::
Programme Advisory Committee, Dept. of Science and Technology
::
Task Force on Multi centre National programme on cervical cancer, Dept. of Biotechnology, Govt. of India
::
Thematic Review Committee for Health Informatics, CDAC, Dept. of Information and Technology, Govt. of India
::
Scientific Advisory committee of Cancer Institute (WIA)
::
Scientific Advisory committee of Vision Research Foundation, Sankara Nethralaya, Chennai
::
Ethical committee of YRG AIDS Research Foundation
::
Asia and Pacific Federation of Organizations for Cancer Control, treatment and research
::
Chairman, Membership Committee, Asia Oceania Organizations (for research on) Gynaecological Infections and Neoplasia
::
Editorial Board, Hereditary Cancer in Clinical Practice
::
Editorial Board, Indian Journal of Cancer
::
Reviewer-British Journal of Cancer, Asia Pacific Journal of Cancer Prevention, Indian Journal of Biochemistry and Biophysics, Indian Journal of Medical and Paediatric Oncology
::
Project reviewer-ICMR, DBT, DST, India and Wellcome trust UK
::
Indian Society of Oncology
::
Indian Association of Cancer Research
::
Indian Society of Human Genetics
::
Asia Pacific Organisation for Cancer Prevention
Type of Neoplasms
Pulmonary system
Lung
Breast
Female, Male
Hemato-lymphoid system
Bone marrow, Lymph nodes